Pathophysiology- gasrtic acid stimulation on PUD,GERD,GASTRITIS Essay

Pathophysiology- gasrtic acid stimulation on PUD,GERD,GASTRITIS - Essay Example There are four main phases in the process of gastric acid production and these include basal phase which is constant acid release into the stomach. The cephalic phase involves the preparation for eating and acid secretion is triggered by impulses from higher CNS structures through CN X. Acid secretion in the gastric phase is due to distention of the abdomen and the intestinal phase is stimulated by amino acids and intestinal distension (Malfertheiner, 2009). There are several disorders that can occur as a result of hypersacidity which include peptic ulcer disease, gastroesophageal reflux and gastritis. The acid accumulation in these cases is due to a series of aggressive factors such as alcohol, h. pylori and NSAIDs. For example in patients with hyperacid dyspepsia due to Helicobacter pylori there is an increase in gastrin production which stimulates the the parietal cells to produce HCl. Dietary factors and consumption of alcohol leads to stimulation of gastric mucosa leading to hypersecretion of acid from the parietal cells (Patel & Gyawali, 2012). Genetics have a role to play in the development of PUD, gastritis and GERD due to several reasons. Firstly, hyperacid dyspepsia can be a genetic condition whereby an individual naturally produces an elevated amount of acid therefore making him or her predisposed to developing the above mentioned conditions. Other genetic conditions such as hyperpepsinogemenia play a role in the development of peptic ulcer disease. Genetic defects of lower esophageal sphincter function also predispose an individual to GERD. Autoimmune disorders, cancers and allergic reactions increase an individual’s chances of developing peptic ulcers or gastritis (Patel & Gyawali,

The expansion and settlement of the U.S Essay Example | Topics and Well Written Essays - 250 words - 2

The expansion and settlement of the U.S - Essay Example However, this process of incorporation and inclusion of territories that had not previously been part of the United States was not something that came about on its own. Instead, it was encouraged by the government, by the press, and by individuals within the United States as something of a â€Å"manifest destiny†. As this confusing phrase implies, the destiny was that the United States was predisposed to conquer and occupy all of the territory between the Atlantic and Pacific, stretching all the way to Mexico in the South and all the way to Canada in the North. The primary rationale for this manifest destiny was that God had given the United States a unique opportunity and all of the lands that it was to occupy. Naturally, this particular rationale is reminiscent of the way in which the God of the Old Testament had given the land of Canaan to the Israelites as immutable; upon their exodus from Egypt. In terms of defense ability, this particular rationale is of course completel y and entirely indefensible. None of the individuals, whether members of the press, members of the government, where members of the individual society, has spoken with God and were able to definitively conclude that this is what you want. Furthermore, such a behavior trampled upon the rights of indigenous peoples and those that had otherwise laid claim to the regions that the United States slowly incorporated into the